Obsada i filmowcy

Chris Rock

Osmosis Jones

Laurence Fishburne

Thrax

David Hyde Pierce

Drix

Brandy Norwood

Leah

Elena Franklin

Shane Detorre

Bill Murray

Frank Detorre

William Shatner

Mayor Phlegmming

Ron Howard

Tom Colonic

Kid Rock

Kidney Rock

Molly Shannon

Mrs. Boyd

Chris Elliott

Bob

Jonathan Adams

Officer Tom

Carlos Alazraqui

Spanish Germ

Keith Anthony

Additional Character Voices

Eddie Barth

Conductor

Sally Brooks

Additional Character Voices

Rodger Bumpass

Joe Cramp / Announcer for Nerve News Network

Michael Carven

Additional Character Voices

Paul Christie

Dan Matter / Germ

Janis Dardaris

Additional Character Voices